"The lower end of dosing appears to be one gram (1,000mg) of citrulline taken thrice a day with meals, totaling 3,000mg at the end of the day. This appears to be somewhat effective for promoting circulatory health and alleviating erectile dysfunction (possible ED associated with high blood pressure).
"For ergogenic (performance enhancing) purposes, a dose in the range of 6,000-8,000mg is taken acutely about an hour before exercise."
1: Surprising that they would think the 1,000 mg x 3 per day would be the LOWER end of dosing.
2. They say to take it WITH meals - and yet my "Now Foods" L-Citrulline bottle's label clearly says to take BETWEEN meals - so both recommendations can't be right. Anecdotally, I've gotten great results taking it BETWEEN meals. Another here had been taking it WITH food and only noticed it working after switching over to BETWEEN meals. I'd think the between meals would be correct?
3. They link L-Citrulline's ED solving properties to those with high blood pressure. I can tell you I have never had high blood pressure - and it works for me. And WebMD (http://www.webmd.com/vitamins-and-supplements/l-citrulline-uses-and-risks) says, "You should also be careful when taking L-citrulline if you take ANY type of blood pressure medicine. So that would seem contradictory?
4. Wow, I'd not be too concerned about taking 3,000 mgs. per day if it is accurate that a "dose in the range of 6,000-8,000mg" is safe for helping with peak performance. And yet WebMD also states: "However, optimal doses of L-citrulline have not been set for any condition. Quality and active ingredients in supplements may vary widely. This makes it hard to set a standard dose."
So, it appears safe for healthy people not on certain meds or specific conditions - even at pretty high doses.